L’acide valproïque, antiépileptique largement prescrit, peut être à l’origine d’ intoxications graves. Après avoir décrit un cas d’intoxication sévère avec. Publisher: Selon des sources tertiaires, la prise concomitante de lorazépam et d’ acide valproïque causerait une interaction médicamenteuse. Ici, nous rapportons un cas rare de SJS déclenché par une combinaison de clobazam, la lamotrigine et l’acide valproïque chez un garçon de 7.

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WO1981000562A1 – Sel melange d’acide valproique – Google Patents

Semi-standard non-polar; Column diameter: Outline Masquer le plan. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen. Further clinical and pharmacokinetic studies are required to determine whether concurrent treatment with lorazepam and valproic acid should be considered as causing a major drug interaction.

Valproic acid, a frequently prescribed antiepileptic drug, may be responsible of severe poisonings. Four weeks after the addition of clobazam, the patient developed SJS with a generalized rash, fever, with liver and kidney involvement, and eosinophilia one week after the initiation of treatment. Top of the page – Article Outline. As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data.


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WOA1 – Sel melange d’acide valproique – Google Patents

Valproic acid, Poisoning, Extracorporeal removal enhancement, l -carnitine, Antidote, Hemodialysis. However, this recommendation could not be validated through an analysis of patients exposed to this interaction in the clinical setting or through a review of the literature. Myproic acid [Trade name]. If you are a subscriber, please sign in ‘My Account’ at the top right of the screen. Boiling Pt deg C: Biowin7 Anaerobic Linear Model: Drugs or Compounds in Development.

Acidose lactique sur intoxication volontaire à l’acide valproïque – EM|consulte

Access to the text HTML. Access to the full text of this article requires a subscription. Danger Alfa Aesar A Outline Masquer le plan. Cependant, la signification clinique de cette interaction est inconnue.

Coadministration of lorazepam and valproic acid is identified by tertiary references as causing a major drug interaction that requires therapy modification and dosage adjustments. A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. Acido valproico [Spanish] [INN].

Access to the Aicde text. Acide valproique [French] [INN]. Biowin3 Ultimate Survey Model: However, the clinical significance of this interaction is unclear.


Comment on this record. Acidum valproicum [Latin] [INN]. You can move this window by clicking on the headline. The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.

Until more data are available, clinicians should remain cognizant of the potential for a drug-drug interaction and should use the lowest effective dose of lorazepam when this drug is administered concomitantly with valproic acid. Canevet bC.

Desaintfuscien aC. Stevens-Johnson Syndrome SJS and toxic epidermal necrolysis TEN are diseases within the spectrum of severe cutaneous adverse reactions affecting skin and mucous membranes.

Our case suggests that a drug-drug interaction between valproate, lamotrigine and clobazam contributed to the development of SJS. Because of inadequate seizure control, lorazepam was replaced with clobazam. Access to the PDF text. Molecular Libraries Screening Center Network.

Depakin chrono [Trade name]. Click to predict properties on the Chemicalize site. When the clobazam was added to valproic acid and lamotrigine co-medication, the lamotrigine dose should have been decreased. You can purchase this item in Pay Per View:

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